Neurosciences and nuclear medicine: modeling and predicting neurorehabilitation of Alzheimer’s disease

The study addresses the problematic issues of neurorehabilitation of Alzheimer’s disease and achieving individual circadian and chronobiological health, increasing the potential for synchronized work of the cognitive and visceral brains of humans. Circadian stress causes sleep disturbance and neuropsychiatric disorders with a suspected high prevalence of circadian dysregulation. The stress response and reproductive cycle are controlled by the hypothalamic-pituitary-adrenal (HPA) axis and the hypothalamic-pituitary-gonadal (HPG) axis, respectively. Neuroendocrine circadian rhythms associated with stress response and reproduction by age-related prediction and mathematical modeling of the HPA and HPG axes as neural networks of interconnected oscillators. The updated complex (hybrid) problem “Alzheimer’s disease” is solved by modeling and predicting neurorehabilitation algorithms (tools, technologies, etc.) of Alzheimer’s disease, with the help of modern achievements of neuroscience and nuclear medicine. Alzheimer's disease is the evolutionary, genetic and epigenetic routing of Homo sapiens, with the introduction of the BAYAM-365/22/77 rehabilitation program (Alzheimer’s disease & nuclear medicine) and medical and social neurocommunications and accompaniments (Neuroscience Research Institute, 2022). New tools of bioelementology and nutritionology of the brain are in demand not only in endocrinology, cardiology, geriatrics, neurology and psychiatry, but also in the long-term work of a qualified mind and in neuroeconomics. The effectiveness and stability of achieving the set targets is ensured by the author’s technologies of multidisciplinary and interdepartmental support of Homo sapiens on eight platforms: educational, religious, medical, social, economic, information, chronobiological and chronomedicine. Strategic is the development and implementation of combined and hybrid algorithms / schemes / tools / enhancement technologies, both the effectiveness of the introduction of new methods of neurophysiological and neuroendocrinological longevity routing, and the achievement of long-term minimization of side effects in H. sapiens.