Neuroimaging features of comorbid depressive disorders in patients with epilepsy

Modern structural and functional investigations of the brain have had a huge impact on the diagnosis and treatment of epilepsy and its associated mental disorders, as it allows to identify changes in the brain structures responsible for epileptogenesis and development of affective disorders. Structural and interregional neuroimaging has demonstrated a high clinical potential, since various mental disorders can develop with abnormalities of aberrant neural connections. Objective: to study the structural-morphological and metabolic features of the brain of patients with epilepsy and associated depression. Material of the study: 142 patients with epilepsy (EP), divided into two groups: 69 patients with epilepsy with comorbid depressive disorders (EPD) and 73 EP without depression. Methods: clinical-psychopathological, neurological, psychometric, neuroimaging-magnetic resonance imaging of the brain (MRI) with a magnetic field voltage of 3 Tesla, diffusion-tensor brain MRI with tractography, single-voxel proton spectroscopy of hippocampus...