On prospects in development of a new concept for preventive medicine

The concept of the Immunculus is proposed. The Immunculus is considered as the system (general network) of constitutive ly expressed natural autoantibodies against very different extracellular, membrane, cytoplasmic, and nuclear self-antigens (ubiquitous and organ specific). It is specially noted that the serum repertoires of natural autoantibodies are nearly constant in healthy persons, independent of gender and age. On the other hand, abnormal metabolic changes which precede the clinical manifestation of any diseases are inevitable triggers of easily detected changes, rather quantitative than qualitative, in the systems of natural autoantibodies in patients sera (immunculus distortions). This phenomena could supposedly be used for.mapping the state of physiological norm in terms of the natural autoantibodies repertoires, and for elaboration of the methods for early (preclinical) detection of potentially pathogenic metabolic changes which may leads to serious diseases. The research project «Immunculus» - as practically oriented additive to project «Human Genome», is proposed for international cooperative investigations.