Does double-energy roentgen absorptiometry allow estimation of mineral matrix physiological metabolism?

Projection bone mineral density (PBMD) of the proximal femur was measured in the dynamics bilaterally with the help of double-energy roentgen absorptiometry (DXA) in 98 patients (63 males, 35 females) at the age from 13 to 75 years with the degenerative diseases or injury sequelae of lower limb large joints (2-7 measurements with the interval from 4 to 42 days), and in two practically healthy male volunteers daily during a month. It was found that in patients PBMD variation scope did not depend upon the time interval between the measurements (a week one or that multiple of it) and amounted on the average to 6.5-8.2 % with the maximum of 10-15 %. In volunteers about-week PBMD variations were revealed (from 4.1 to 9.3 days with the maximum variation scope of 14.0 % and 0.8 in T-scale in one and from 4.7 to 7.3 days with the maximum value of 17.2 % and 2.0 in T-scale - in the other). The obtained data demonstrate the registered PBMD physiological variations might have a considerable influence on DXA findings in diagnosing osteoporosis and controlling its treatment. The possibilities of using quick PBMD changes in clinical practice are discussed.