Evaluation of antiaminetic action of nootropes in animals with experimental traumatic brain injury under normobaric hypoxic training

The objective of the paper is to evaluate the influence of nootropic agents on cognitive processes in animals with experimental traumatic brain injury under normobaric hypoxic training.Materials and Methods. White laboratory mice weighing 20-30 g were enrolled in the trial. To cause contact traumatic brain injury (TBI) the animal’s head was exposed to a free falling weight (1.5 g), fixed height 1 m. The animal was injected intraperitoneally with Nembutal (50 mg/kg). The model of experimental TBI described in the paper corresponds to brain concussion. Normobaric hypoxic training was carried out during post-traumatic period (2nd-12th days, 9 consecutive cycles) in a 250-ml hermetic chamber. One cycle included breathing a normobaric hypoxic gas mixture (15 min.) in a hermetic chamber, alternated by a 5-min. episode of breathing with atmospheric air. Nootropic drugs were injected 30 min. before the normobaric hypoxic training. The anti-amnestic properties of piracetam, nooglutil, pantogam, and isonitrosine were studied...