Evaluation of the effectiveness of treatment of knee osteoarthritis by monotherapy with intraosseous infiltration autologous platelet-rich plasma

Abstact. Osteoarthritis (OA) of the knee is a degenerative disease of the entire joint, including cartilage, synovial membrane, subchondral bone, menisci and ligaments. If for each pathologically changed component of the joint there are specific therapeutic and surgical methods of treatment, then in the literature there is little information about methods aimed at treating the altered subchondral bone, which is a new approach to the treatment of gonarthrosis.The aim of the study: is to develop a method for the treatment of gonarthrosis by the local injection into the subchondral bone of autologous platelet-rich plasma (as monotherapy)Materials and methods: the work presents 26 patients with a diagnosis of OA according to Kellgren-Lawrence 2-4 tbsp. OA. Patients received a local intraosseous injection of autologous platelet-rich plasma into the subchondral bone under the control of a Mobile C-arm Image Intensifier (X-ray) without penetration into the joint. Clinical assessment of the effectiveness of treatment was performed on the VAS, WOMAC and KOOS scales before the drug was administered, 1 and 3 months after the start of treatment, and laboratory efficiency was assessed by taking blood from the patients' veins to the Cartilage Oligomeric Matrix Protein (COMP) before the drug was administered and after 1 and 3 months after starting treatment...