Assessment of cumulative effects nanodisperse silicon dioxide in experiment in vivo

Estimation of the cumulative action of nanosized silica in experiment in vivo revealed that the intragastric gavage male rats of Wistar line weight of 190 ± 10, at 4 days in a dose of 365.9 mg / kg (total dose was introduced 1464 mg / kg ) of causing the death of 50%. After a single dose nanosized silica LD 50 - 3659 mg / kg. It has been established that the the coefficient of cumulation of 0.4, that in accordance with the method proposed by RKS Lim and colleagues, indicates the presence cumulative properties of nanosized silica.