The assessment of acute phase response for experimental osteosynthesis using implants with bioinert coating of superhard metal nitrides

Purpose. Comparative studying the changes in blood composition of experimental animals when using the implants of medical steel and medical steel with coating of titanium and hafnium nitrides. Materials and Methods. The comparative study of the effect of titanium and hafnium nitride coating on the rabbit blood condition experimentally. The animals undergone osteoclasia and further osteosynthesis with a wire of bioinert medical steel served as a comparison group. Results. In the experimental group of animals such acute phase markers of response as the level of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), relative growth of granulocyte number in blood normalized in shorter periods than in the comparison group. The postoperative inflammation providing systemic and local regulation of humoral and cellular mechanisms involved in restoration of the damaged bone tissue not accompanied by complications in case of implanting steel with titanium and hafnium nitride coating. Conclusion. The study revealed that the reactive phase after osteotomy and osteosynthesis was of short-term character, and its manifestations were somewhat less marked in case of using implants of steel with titanium and hafnium nitride coating comparing with implantation using bioinert medical steel.