Evaluation of rat behavior activity during acute intoxication by insectoacaricides in the open field test

Insectoacaricides of different chemical groups are potential neurotoxicants that modify the innate behavior of animals. The purpose of the study is to evaluate the behavioral responses of rats in the Open field test during acute experimental intoxication with insectoacaricides. The study was conducted on 30 outbred adult white rats weighing 250 ± 20 g, divided into two experimental and one control groups. Ivermin (an active ingredient - ivermectin) and Clothiamet (an active ingredient - clothianidine) were used to model acute intoxication with insectoacaricides. Evaluation of affectomotor activity indicators of rats was designed in the Open field test. Testing of animals was performed twice: 30 minutes and 48 hours after a single intragastrical injection of drugs in doses of 40 mg/kg. In case of acute intoxication with Ivermin, an arousal effect in animals resulting in an increase in the orientation and locomotor response within 48 hours after intoxication has been established...