Evaluation of the blood-brain barrier permeability and development of autoimmune reactions to the S100B protein in the prehypertension / hypertension system

The aim of the study was to assess the permeability blood-brain barrier on the basis of a comparative blood serum assay of the neurospecific protein Sl00b content, as well as the detection of autoimmune responses to Sl00b in patients with "optimal" arterial pressure, prehypertension and hypertension. Methods. The clinic-biochemical examination of individuals aged 30-60 years with "optimal" arterial pressure, (control group, n=63, BP 140/90 mm Hg) was performed. In the blood serum of all individuals by solid-phase enzyme-linked immunosorbent assay (ELISA) using the original and commercial test systems, the concentration of the protein Sl00b, as well as the level of autoantibodies to Sl00b was determined. Results. It was found that in the 52% prehypertensive patient serim, an increase of the S100b protein content was detected in comparison with a group of individuals with "optimal" arterial pressure, which may indicate a violation of the functional state of blood-brain barrier already in the prehypertension stage...