Estimation of toxicity of SiO2, Zn, and ZnO nanoparticles under UV light

The aim of the paper is to obtain information on the effect of UV irradiation of aqueous suspensions of SiO2, Zn, ZnO nanoparticles on the morphofunctional characteristics of cultured human and animal cells. Materials and Methods. The authors examined the effect of UV irradiation exposure time (1, 2, 5 min) on the biological activity of SiOi, Zn, ZnO nanoparticles (NPs). The test objects were transplantable Hep-2 cultures (human laryngeal carcinoma cells) and RD (human rhabdomyosarcoma cells) obtained from the Russian collection of cell cultures, the Institute of Cytology, Russian Academy of Sciences (St. Petersburg, Russia). MTT-test was used to determine the cytotoxic effect of the analyzed substances. The cytotoxicity and viability indices were also calculated. Results. The study of the cytotoxic effect of the above-mentioned nanomedicines demonstrated different characteritics in different nanoparticles. Thus, human rhabdomyosarcoma cells are more susceptible to irradiated Zn and ZnO nanoparticles than human laryngeal carcinoma cells...