Possibilities for optimization of antibacterial therapy of infections caused by carbapenem-resistant enterobacteriales

The result of treatment of patients with severe sepsis directly depends on timely prescribed adequate antimicrobial therapy. An increase in the number of infections caused by carbapenem-resistant Enterobacteriales, including Klpneumoniae, complicates the selection of an adequate empirical antibiotic therapy regimen. Early detection of the ability to produce carbapenemase in Klpneumoniae is a real opportunity to optimize antibiotic therapy, timely appointment of an adequate antimicrobial therapy regimen. The assessment of risk factors for carriage of carbapenem-resistant strains of Enterobacteriales makes it possible to identify a group of patients at risk of carrying such strains of Enterobacteriales, to use methods of early detection of antibiotic resistance genes in Enterobacteriales more widely in this group and to use appropriate effective antibiotics as a starting empirical therapy.