Specific dynamics in vascular endothelial growth factors (VEGF) in blood of patients with vitamin D-resistant rickets during correction of multiplanar deformities of lower limbs

Background Vitamin D-resistant rickets is a systemic disease with impaired bone remodeling that interferes with orthopaedic treatment of musculoskeletal pathologies. There is a paucity of literature focusing on the content and dynamics in vascular endothelial growth factors (VEGF) that promote the transformation of cartilage to bone. Objective Explore blood serum concentration of VEGF and VEGF-А and their receptors VEGF-R2, VEGF-R3 at stages of combined osteosynthesis in patients with vitamin D-resistant rickets during correction of multiplanar deformities of lower limbs. Material and methods The study included 24 patients with multiplanar deformities of lower limbs secondary to vitamin D-resistant rickets. Patients were treated with combined Ilizarov external fixation and intramedullary nailing using hydroxyapatite-coated wires. Serum concentration of VEGF and VEGF-А and their receptors VEGF-R2, VEGF-R3 were measured during treatment. Values obtained in the patients were compared to reference levels measured in 180 somatically healthy individuals...