Features of genetic and immunological parameters in the workers of continuous production cycle

The aim of the research was to study the polymorphism of candidate genes in non-ferrous metallurgy workers, operating in night shifts regime. Genetic analysis is carried out using the polymerase chain reaction in real time with the evaluation results by the allelic discrimination. SNP-established violations according to the criterion of occurrence of variant alleles of genes of phase 1 detoxification, neuro-endocrine regulation and oncogenesis (excess performance comparison group for each group of genes in 1.5 times), the functions of carbohydrate and energy metabolism (in excess of the comparison group index of 2.0 times). Evaluation of immune status showed that the mode of work night shifts with conditions promote inhibition of the expression CD16 +, CD127- (1.2-1.5 times relative to the control group) and transcriptional activation of intracellular proteins Bcl-2 and bax (1.8-fold relative to the control group). Indicators of immune regulation (CD127-, Bcl-2, bax), as well as the Candidate alleles of genes CYP1A1 (1506C/T), TP53 (rs17884159), PPaARG (rs2016520) recommended for use as a marker of early indicators of health problems when working night shifts.