Features of immune regulation and apoptpsis in children under industrial exposure

The study of the features of immune regulation and apoptosis in children of preschool age living in industrial pollution conditions revealed elevated levels of contaminants (aluminum, manganese, chromium, formaldehyde, benzo(a)pyrene, xylene) in the biological media, a decrease in the content of CD19+-lymphocytes, CD3+- and CD4+-cells by 1.53, 1.38 and 1.59 times, respectively, relative to the indicators of the comparison group, an increase in CD3+CD95+-lymphocytes by 1.80 times and in the expression level of the activation marker CD25 by 2.59-3.84 times, as well as the number of regulatory CD4+CD25+CD127--lymphocytes in 85.0-100.0% of children of the observation group regarding the reference interval and by 2.45-3.58 times relative to the comparison group. We showed the disruption of apoptosis triggering processes via CD95 and TNFRI, the expression of which was also increased by 3.20 times concerning the levels in the comparison group, and a change in the balance of regulatory factors, associated with an increase in the expression of the anti-apoptotic Bcl-2 protein in 75.0% of the children relative to the reference range and by 7.01 times regarding the comparison group. A decrease in the concentration of serum immunoglobulins IgG and IgM was noted, by 1.42 and 1.47 times relative to the comparison group, a raise in the level of specific antibodies IgG to aluminum was detected in 72.2% of the examined population, when compared with reference indicators, as well as in the content of IgE to formaldehyde by 6.01 times, IgG to aluminum and benzo(a)pyrene by 2.66 and 2.22 times concerning the comparison group. The shown changes in the immune indices of the examined population make it possible to determine the marker features of the state of the immunological health of the population under the conditions of active industrial development of the environment.