Features of IBA1 expression in the primary somatosensory cortex of rats with experimental type 1 diabetes mellitus

The purpose of the study. To characterize the features of Iba1 expression in the primary somatosensory cortex in experimental type 1 diabetes mellitus (T1DM). Material and methods. Diabetes mellitus was modeled on 12-month-old white outbred female laboratory rats. The animals were divided into 5 groups: intact group, untreated type 1 diabetes mellitus group, and pharmacological correction group with aminalon, mefargin, and succicard. Diabetes mellitus (DM) was modeled by a single intraperitoneal administration of streptozotocin (Sigma, USA) dissolved in citrate buffer (0.1 M, pH 4.5) at a dose of 60 mg/kg after 48-hour food deprivation. Treatment was started 6 months after modeling DM. Statistical processing of the obtained results was performed by descriptive and analytical statistics methods using Prism 6 software (GraphPad Software Inc., USA).