Features of NF-KB expression in the outer granular and outer pyramidal layers of the motor cortex of rats with experimental type I diabetes mellitus

The aim of our study is to characterize the features of Nf-kb expression in the outer granular and outer pyramidal layers of the motor cortex of the brain in diabetic encephalopathy. Immunohistochemical examination of the inner pyramidal layer of the motor cortex revealed the following differences between the intact and untreated type I DM groups: in the untreated type I DM group, the expression of Nf-kb IRM was observed mainly in the nuclei of damaged neurons in the form of lumps, in the intact group - in the cytoplasm of intact pericaryons. In the intact group, the expression of IRM was detected in vertically positioned axons of neurons, in the group of type I diabetes without treatment, the expression of Nf-kb in vertical processes was not detected. Specific changes were also observed in the pharmacorrection group: the picture of the immunohistochemical description of the aminalon group, succicardium, to a greater extent corresponded to the picture of the intact group. In the group of pharmacorrection with mefargine, the picture is similar to that of type I diabetes without treatment.