Bone metabolism features in patients with morbid obesity

The article presents the literature data and the results of our own research concerning the violations of bone metabolism in the long term after bariatric operations. The study observed the parameters of bone metabolism in morbid obesity (MO), including the cases after bariatric interventions. The first group consist- ed of patients with a body mass index (BMI)> 40; the second group - patients who underwent bariatric interventions; the third (control) group is healthy people who do not have obesity and overweight. The three groups differed in the level of bone resorption markers and indicators of bone formation. In the course of the study, we found a tendency of prevailing of bone resorption processes among the patients with MO compared with the control group. There was also a sharp tendency towards the development of osteopenic conditions among the patients undergoing malabsorptive types of bariatric interventions, and no such pathology was revealed in the control group. The comparison of bone metabolism in the first and the second groups confirmed the tendency to develop osteoporosis among the operated patients, and in patients with restrictive type of bariatric interventions with minimal risk.