Features of lower respiratory tract microbiocenosis in patients with a combination of occupational COPD and type 2 diabetes mellitus

The aim of the study was to determine the features of the lower respiratory tract microbiocenosis in patients with a combination of professional chronic obstructive pulmonary disease (COPD) and diabetes mellitus type 2 (T2DM). Material and Methods: The study included 123 patients with occupational COPD, 61 of them had T2DM. General clinical examination, investigation of fasting glucose and HbA1c levels, pulmonary function testing, microbiological examination of sputum were carried out in all patients. Results: The risk of detecting microbial associations increased by 4.5 times, and the relative risk of isolation of Haemophilus spp. was 3.1 [95%CI 2.0-5.0], enterobacteria and enterococcus - 5.5 [95%CI 1.3-24.2] in patients with professional COPD and diabetes mellitus type 2. The number of microorganisms in sputum cultures correlated with the severity of bronchial obstruction and the level of glycemic control: a relationship was found between the total microbial load and the value of HbA1 с (/=0.71, p