Manifestations of chronic feed mycotoxicosis in laboratory rats under experimental conditions

Mycotoxicoses are specific human and animal diseases caused by the certain types of microspores fungi that during their life form toxic substances, the mycotoxins. Toxic effects of these diseases are diverse and depend on the dose of toxin, exposure, animal species, age and sex. Lack of data on physiological mechanism of the pathological influence under combined mycotoxicoses significantly reduces the development of new drugs and methods for treatment of animal mycotoxicoses. This paper is our first report on the features of the clinical, biochemical, and pathomorphological signs of associative mycotoxicoses under experimental exposure of laboratory animals to the most common mycotoxins. The aim of the research was studying clinical signs of chronic combined mycotoxicosis and pathoanatomical changes in organs and tissues under experimental mycotoxins in laboratory rats, as well as the characteristics of intoxication symptoms, the effect of mycotoxins on the reproductive function of rats and their progeny, and morphobiochemical blood parameters...