Features of hemostasis under conditions of high-mountain hypoxia

The impact of the blast wave on hemostasis leads to successive hyper and hypocoagulable shifts in the hemostasis system in experimental animals in low mountains (1100 m above sea level) with a tendency to hypofibrinogenemia and a shortening of blood clotting at the 6th, 8th and 10th minutes. Research objectives: to study features of the hemostasis in conditions of high-mountain hypoxia. Research materials and methods: to study the features of the state of hemostasis in conditions of high-mountain hypoxia, a number of experiments on animals (rabbits) were carried out. Were used 60 healthy animals (rabbits) with an average weight of 2500-300 grams. Research results: in animals in the high mountain zone, an increase in the number of platelets was observed, more pronounced than in low mountains, an increase in the adhesive ability (5, 10, 15 m) and aggregation (10, 15 m) of platelets. Conclusions: the action of the blast wave in high altitude conditions caused the development of disseminated intravascular coagulation syndrome (DIC-syndrome) with a more pronounced hypercoagulable pattern, especially in animals located 5 meters from the center of the explosion.