Passive hyperthermia is a promising "exercise mimetic" for the elderly

Extending a healthy life of a modern person and slowing down the development of ageing processes is an urgent problem for public health and all social institutions. In a broader sense, it refers to the formation of a culture of health as one of the main components of the ecological culture of modern man. Obviously, it is the crisis of ecological culture as a whole that is the cause of the unfolding civilizational rift and the degradation of anthropo-ecosystems. At the individual level, it is possible to slow down aging processes by modifying lifestyle, regular physical activity, many effects of which are associated with the production of special peptides - myokines by active muscles. Given the limitations of sufficient physical activity in the elderly, it is important to develop methods that can complement and enhance the effects of physical activity. The use of myokine-based pharmacological agents has little scientific evidence. This paper discusses the rationale and evidence base for passive hyperthermia/regular heating of the human body as a «mimetics of physical activity». The evidence for the efficacy and safety of the method, including the induction of myokine secretion - irisin and BDNF - and their positive morphofunctional effects, as well as the potential challenges and prospects for the use of passive hyperthermia in the elderly are presented.