Pathologic features in area Ca1 of rat hippocampus after forced chronic alcoholization

The qualitative analysis of pathomorphological changes in the pyramidal, molecular layers and lacunar sublayer of the CA1 zone of rat hippocampus during forced chronic alcoholization was carried out. Signs of development of compensatory-adaptive and neurodegenerative processes in the pyramidal, molecular layers and lacunar sublayer of the CA1 zone of the hippocampus were found in alcoholic animals, with different degrees of severity of morphological changes were revealed in the hippocampus of intact rats, which probably indicates a constitutional tendency to formation of alcohol dependence in some animals and emphasizes the importance of taking into account constitutional features in modeling of experimental alcohol intoxication.