Pathomorfologiс analysis of organs of hepatopancreatoduodenal zone when fatty pankreonekroze and its correction with sadostatinom (experimental study)

The aim of the research was to study the particularities (features) of morphogenesis of experimental acute fatty pancreonecrosis, induced by duct hypertension and injecting phospholipase a2 and evaluate the properties of sandostatin to protect organs. 180 white Wistar rats were used for experimental research. The creation of models of acute experimental pancreatitis was carried out due to (with the help of) 2 basic pathogenetic factors forming mainly fatty pancreonecrosis (duct hypertension and activation of phospholipase). Animals were divided into 6 groups. Each group consisted of 30 animals. The dynamic of the development of progressive fatty pancreonecrosis (when all visceral organs are involved into the process and high level of mortality is matched) is shown in the enumerated models of acute experimental pancreotitis (3 groups of animals). The research showed that the application of sandostatin beneficial effect on pancreas and other organs of the abdominal cavity, stopped the progression of the process, eliminates the cell necrosis and pancreatogenic intoxication with high survival of animals. The research showed that the usage of sandostatin had distinct positive effect on the pancreas and other abdominal organs and stopped the progress of the process, eliminated cell necrosis and systemic pancreotogenic intoxication with high probability of survival of animals.