Lipid peroxidation in treatment of closed shaft fractures using hyperbaric oxygenation

The comparative analysis of biochemical studying blood plasma of patients with closed shaft fractures of leg bones is given during treatment by the transosseous osteosynthesis technique according to Ilizarov using hyperbaric oxygenation and patients treated without HBO-therapy. The concentration of peroxidation products was determined in blood plasma of 33 patients and enzymatic activity of superoxide dismutase (SOD) was determined in erythrocytes. The results of the study demonstrated activation of peroxidation reactions, accompanied by SOD inhibition in the groups of patients with HBO use unlike the group of patients without HBO use. On the basis of the study made the authors came to the conclusion about the necessity of limitation of HBO course duration and the possibility of correction of lipid peroxidation with the help of antioxidant preparations.