Pancreas as a source and a target of autoenzymatic aggression. Methods of its correction with adder antivenene (experimental study)

The aim of the research was to examine experimentally the role of the pancreas in the development of autoenzymatic aggression and evaluate methods of its correction with adder antivenene. 168 white Wistar rats were studied during the experiment. The effectiveness of treatment with the help of adder antivenene was studied using these rats. While modeling acute experimental pancreatitis with the help of tripsin and adder venom hemorrhagic pancreonecrosis affecting all visceral organs, shock and polyorganic insufficiency developed as a result of autoenzymatic aggression. Injecting of tripsin and adder venom into cellural tissue of retroperitoneal space provoked local oedematic and necrotic process but without hemodynamic shock and necrobiotic changes in pancreas and other organs. The use of the adder antivenene is effective concerning all the models. Thus it must be taken as proved that pancreas is a source and a target of autofermental aggression. The use of the adder antivenene stops the development of the pathological process both of local and general character neutralizing the enzymatic aggression, and opens prospects for further research of this medication in the clinical practice curing diseases with the development of uncontrolled proteolysis where tripsin plays one of the main roles.