Parameters of hemostasis system in patients with atherosclerotic peripheral arterial disease

The study included 120 patients with PAD. All patients had stage ІІВ-ІІІ of the disease according to Fontaine classification. 40 patients with PAD underwent open and endovascular interventions for aorto-femoral-popliteal segment (groups A and B) and 40 patients underwent conservative treatment (group C). Patients underwent physical examination, ankle-brachial index measurement (ДВІ), duplex ultrasound (DUS) and digital substraction angiography. After 3, 6, 12 months after treatment patients underwent underwent the same procedures. At inclusion in the study and 3 months after surgery peripheral venous blood samples were collected to assess the activity of VIII, ІХ, ХІ, von Willebrand factor (VWF), protein С (PrC) and metabolites of nitric oxide ІІ (NO). In patients groups А and В mean values of activity VIII, ІХ, ХІ factors and VWF was increased in comparison with the norm before surgery. After 3 months results shown a greater increase in activity VIII, ІХ, ХІ factors, VWF in the reduction of NO metabolites...