Angiotensin-converting enzyme gene polymorphism., the clinical course and the structural and functional state of the heart at the Uzbek patients with dilated cardiomyopathy

Background. The study of genes polymorphism of angiotensinconverting enzyme (ACE) and their contribution to development and clinical course of dilated cardiomyopathy (DCM), and the possibility of early diagnostics and differentiated pharmacotherapy in early and advanced stages of the disease, is a promising new area of medical genetics and cardiology research. The aim. To study the genes polymorphism of angiotensinconverting enzyme (ACE) at DCM patients in the Uzbek population, to reveal the feature of heart remodeling depending on a genotype, and also an estimation of Lisinopril efficiency at these patients. Material and methods. It has been surveyed 102 DCM patients of the Uzbek nationality, with II-IV classes by NYHA. Besides an estimation of the clinical status (test of six-minute walking, clinical status estimation score (in Mareev modification) it has been spent 12-led ECG, EchoCG, Holter ECG, rentgenkardiometriya. These data were analyzed depending on the revealed genotype. Results. For the first time we have studied the genes polymorphism at Uzbek DCM patients. It has been showed feature of clinical and instrumental data depending on genotype, and also revealed unfavorable types of gene inheritance. It has been noted a high efficiency of Lisinopril application at DCM patients depending on the ACE- genes polymorphism.