Threshold activation of blood coagulation as a result of elevated wall shear stress

The processes of blood coagulation cascade activation in stenosed vessels are investigated in a wide range of Reynolds numbers (𝑅𝑒 ∈ (50, 350)). In regions of high wall shear stress the vessel wall permeability increases. This leads to the infiltration of procoagulants into a blood flow and blood coagulation activation. The results of numerical simulations demonstrate that the blood coagulation cascade can appear not only as a result of the blood flow rate decrease, but also as the activation result of its increase. The relevance of obtained results to clinical practice is discussed.