The ultrastructure development of rat brain histaminergic neurons in postnatal ontogenesis

The brain histaminergic system plays an important role in the regulation of many functions, systems and reactions of the body. In adult mammals and the human, histaminergic neurons are located exclusively in the hypothalamus, mainly in its tuberomammillary part, where they form five clusters - nuclei (Е 1 - Е 5). The aim of the study is to evaluate the ultrastructural changes in histaminergic neurons of the E2 nucleus of the rat hypothalamus in postnatal ontogenesis. Using electronic microscopy it was established that in the process of postnatal development histaminergic neurons become larger, the quantity of all cell organelles increases in their cytoplasm, the number of nucleoli goes down, the amount of ribosome subunits gathering near the karyolemma decrease, the contours of which become more straight, the size of the nucleolar-like bodies in cytoplasm reduces.