APPLICATION OF MALDI TARGET ELECTROPHORETICALLY MODIFIED WITH TiO2 FOR MASS SPECTROMETRY WITH SURFACE-ASSISTED LASER DESORPION / IONIZATION
Автор: A. Yu. Gorbunov, I. M. Zorin, S. K. Ilyushonok, A. A. Bardin, O. A. Keltsieva, N. V. Krasnov, V. N. Babakov, E. P. Podolskaya
Журнал: Научное приборостроение @nauchnoe-priborostroenie
Рубрика: Приборостроение физико-химической биологии
Статья в выпуске: 1 т.31, 2021 года.
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In this investigation, parameters of electrophoretic deposition (EPO) of TiO2 nanoparticles on stainless steel substrate have been optimized. The obtained coating was used as ion emitter during surface-assisted laser desorpion/ionization (SALDI). Herein, we demonstrate the high efficiency of obtained coatings for SALDI of amiodarone with subsequent Fourier transform ion cyclotron resonance mass spectrometry. Additional modification of coatings with polydimethylsiloxane (PDMS) allowed to significantly improve the sensitivity of SALDI-MS analysis.
SALDI-MS, TiO2, electrophoretic deposition, amiodarone
Короткий адрес: https://sciup.org/142226567
IDR: 142226567 | DOI: 10.18358/np-31-1-i4458
