Prognosis and progress of breast cancer during pregnancy or lactation: viral and genetic features

Clinical-pathological features were analyzed in 68 patients suffered with pregnancy-associated breast cancer (PABC) depending on the tumor receptors, histology, BRCA1/2 mutations and MMTV-related proviral sequences occurrence. A frequency of the 5382insC mutation in the exon 20 of BRCA1 gene in PABC patients was signifcantly higher than in age-matched sporadic BC ones (17.6% against 5% ). The MMTV-related sequences in PABC patients were also revealed more frequently than in sporadic BC ones (63% against 39%). The overall and recurrence-free survival rates in MMTV-positive patients with PABC were signifcantly less than in the MMTV-negative patients. Importance of the data obtained for PABC early diagnosis and prognosis is under discussion.