Nail psoriasis: the first experience of photodynamic curcumin therapy

Aim: to determine the effectiveness of the photosensitizer "Curcumin" in various concentrations (0.15%, 1%, 1.5%) in combination with visible spectrum radiation in the treatment of nail psoriasis. Material and Methods. 6 patients (4 women and 2 men) of different age groups (from 20 to 50 years) with the established diagnosis of "Psoriasis" were observed. The study was carried out using the "Curcumin" photosensitizer solution, the broadband spectrometer "Ocean Optics USB4F01891", the LS-55 spectrometer, the PhotoDyn-750 and the THORLABS PM100D. To assess the dynamics of the pathological process, the N-NAIL Index was used. Results. The most pronounced and clinically significant changes were detected when using a 1.5% solution of the "Curcumin" photosensitizer. Conclusion. The photosensitive agent "Curcumin" is effective in photodynamic therapy of psoriasis of the nails.