Reactance of blood circulation to acetylcholini at adaptation to the cold

Reactance of system pressure and peripheral arteries to acetylcholin changes opposite at the expense of change of sensitivity of receptors and their quantity. The reduced reaction of system pressure to all doses acetylcholin for 30th day cold adaptations was below the control exclusively at the expense of decrease in sensitivity М-2-cholinoreceptors of heart in 3,6 times, and quantity М-2-cholinoreceptosr has not changed. The carried out researches have shown, that after 30 days cold adaptations weakening action acetylcholin on arterial vessels exclusively at the expense of increase in sensitivity М-3-cholinoreceptor at 233% increases., and the quantity active М-3-cholinoreceptor for 30th day cold adaptations has decreased for 41%.