Radical surgery outcomes in colorectal cancer patients aged younger and older than 75 years
Автор: Toneev E.A., Pavlov M.O., Alieva G.G.
Журнал: Сибирский онкологический журнал @siboncoj
Рубрика: Клинические исследования
Статья в выпуске: 4 т.24, 2025 года.
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Objective: to evaluate surgical treatment outcomes in colorectal cancer patients aged younger and older than 75 years. Materials and methods. A retrospective analysis of medical records was conducted for 582 colorectal cancer patients treated between January 1, 2019, and December 1, 2024, at the Department of Abdominal Oncology Surgery, Regional Clinical Oncology Hospital, Ulyanovsk, Russia. Based on inclusion and exclusion criteria, 572 patients were included in the study. Postoperative complications were assessed using the Clavien–Dindo classifcation, and tumors were staged according to the TNM system. The patients were categorized into two age groups: a younger group consisting of patients younger than 75 years, and an older group including those aged 75 years or older. Results. Univariate analysis revealed no statistically signifcant differences in baseline clinical and demographic characteristics or comorbidities between the patient groups. However, the Charlson comorbidity index was signifcantly higher in patients aged 75 years and older (p < 0.001). Compared to the younger group patients, the older group patients more frequently underwent right-sided hemicolectomy (58, 56.9%), followed by sigmoid colon resection (38, 37.3%). The incidence of anastomotic leakage was higher in older patients than in younger patients, but this difference did not reach statistical signifcance (p = 0.065). No signifcant differences in postoperative complications stratifed by the Clavien–Dindo classifcation were found between the patient groups (p = 0.247). Multilevel logistic regression identifed the following predictors of anastomotic leakage: preoperative albumin level, albumin level on postoperative days 1 and 5, as well as the neutrophil-to-lymphocyte ratio on postoperative days 1 and 5. Conclusion. Patient age is not considered an independent factor for anastomotic leakage after colorectal cancer resection. Signifcant predictors of anastomotic leakage include NLR on postoperative days 1 and 5, as well as preoperative albumin levels and albumin levels on postoperative days 1 and 5.
Colorectal cancer, surgery, patient age, colorectal anastomotic leakage
Короткий адрес: https://sciup.org/140312272
IDR: 140312272 | УДК: 616.34-006.6-089-053.9 | DOI: 10.21294/1814-4861-2025-24-4-54-65