Significance of immunohistochemical markers in diagnostics of urinary bladder cancer

On the basis of surgical and biopsy material 106 patients with diseases of urinary bladder have been under study. They received treatment at Scientific Research Institute of Fundamental and Clinical Uronephrology of Saratov State Medical University. 13 immunohistochemical markers have been evaluated: markers of proliferative activity - Ki-67, PCNA, p63, suppressor of tumor growth - p53, markers of apoptosis - Bcl-2, Bax, receptor of epidermal growth factors - EGF R, cytokeratin profile - (CK 7, CK 8, CK 10/13, CK 17, CK 18, CK 19), as well as their diagnostic significance for identifying the urinary bladder cancer.