Role of tumor supressor p53 in genesis of angiogenic phenotype of a neoplasm in course of ovarian carcinoma

The parameters of a vascular bed (vascular volume in % and vascular dencity on 1 mm2 of tumor) were estimated on the operational-bioptic aspirate of the primary tumor of 83 patients with the ovary cancer (OC). The immunohistochemical method with the use of mice monoclonal antibodies p53, clone DO-7, IgG2b (M7001 DakoCytomation) has been applied for the estimation of the level of p53 expression. Based on the estimated parameters we can conclude that there is no distinctive group of differences among the different clinical stages of the OC. However, there is a weak positive correlation between the volume and density of vessels and the disease stages. At the same time, the quantity of the atypical epithelial cells of the primary tumor that express p53 is significantly increasing in each subsequent stage. The results of the research show the possible p53 inactivation in the tumor cells and the stimulatory role of p53 in the neoangiogenesis in the course of the tumor progression.