Pandora syndrome in cats

What is Pandora Syndrome? The name for this group of diseases has gone through several changes over the past 50 years. Foreign scientists have recommended such names as Feline Urological Syndrome (FUS) or Feline Urinary Tract Disease (FLUTD). Dr K. A. Buffington coined the term ‘Pandora Syndrome’, thereby illustrating that the disease carries a multitude of complications arising from a single cause. Results of studies indicate that idiopathic/interstitial cystitis in cats is the result of complex interactions between the bladder, nervous system, adrenal glands, husbandry practices, and the environment in which the cat lives. The purpose of this review is to summarize research investigations into the various abnormalities present in cats, to compare some of these findings with those identified in human beings, and to discuss how they might modify perceptions about the etiopathogenesis, diagnosis, and treatment of cats with this disease.