Concentration of nitric oxide derivatives in blood of cancer patients with cerebral metastases and with different grade of endogenous intoxication

The concentration of nitric oxide derivatives (NO-hemoglobin, NO-glutathione, NO-tyrosine and peroxynitrite) and parameters of endogenous intoxication in plasma of cancer patients with cerebral metastases were studied. It was found the damaged detoxication function of albumin and increased concentration of NO-derivatives in blood plasma depending on the extent of metastatic involvement of the brain with progression of endogenous intoxication due to decrease in albumin-bound ability. The data obtained allow for the assessment of the role of NO-derivatives in tumor dissemination and their participation in the development of endotoxicosis