Sorption extracorporal detoxification in intensive therapy of severe sepsis

Objective: the aim of this work was to study the results of treatment of patients with severe sepsis based on the inclusion of modern methods of extracorporeal detoxification in the process of complex intensive care.Material and methods: a randomized controlled study was conducted taking into account the data of the clinical and diagnostic characteristics of two groups of patients with sepsis:Study group (n = 30) - patients who underwent hemodiafiltration at the earliest possible time after the development of septic shock with the inclusion of a highly selective cytokine adsorber in the circuit for 6 hours.The control group (n = 30) - patients who underwent hemodiafiltration with bicarbonate buffer replacement solution for 6 hours under the conditions of complex intensive therapy for septic shock.A statistically significant decrease in the actual 28-day mortality rate in the study group compared to the control group of patients served as a direct criterion of effectiveness.Results: The 28-day mortality rate in the main group was 20%, which indicates better results compared to the control group, where the mortality rate was 50%.Conclusion: the inclusion of a highly selective cytokine adsorber in the complex therapy of severe sepsis has a positive effect on the course and prognosis of the disease.