Immune status of patients with chronic generalized periodontitis

This study was undertaken to analyze the immune status of patients with chronic generalized periodontitis. We found that changes in the immune status play an important role in the pathogenesis of chronic generalized periodontitis, which affect the disease course. Patients demonstrated both general alterations in the immune status, typical of all clinical groups (such as changes in T-cells and B-cells), and specific changes, typical of certain types of disease course. Patients from the first clinical group presented with a reduced immunological reactivity of the organism. Immunological changes in the second clinical group included the development of sensibilization and signs of allergy, whereas patients in the third clinical group had symptoms of autoimmune processes.