Medical care for breast cancer patients in the Amur region for the period 1999-2014

Diffusion-weighted magnetic resonance imaging (DW MRI) provides information regarding tissue microstructure. Furthermore, diffusion-weighted images (DWI) can be used for differentiating benign from malignant tumors. Purpose: to compare the values of apparent diffusion coefficient (ADC) of meningiomas with cell density and the tumor proliferation index (Ki-67). Material and methods. The study included DWI images of 37 patients with brain meningioma. The slice with the largest diameter of meningioma was selected for ADC calculation. Cystic and necrotic areas of the tumor were not included into the region of interest. Histopathological examination of meningiomas analyzed the tumor grading according to the WHO classification, Ki-67 tumor proliferation index and cell density in tumor tissues. Results. Typical (grade I) and atypical (grade II) meningiomas were identified most frequently (37.8% and 56.7% of cases, respectively. Anaplastic (grafde III) meningiomas were verified in 5.5% of patients. The mean ADC value for grade I meningiomas was 1375.5 ± 197.5 mm2/s. The mean ADC values for grade II and grade III meningiomas were 1113.1± 180 mm2/s and 689 ± 31.1 mm2/s, respectively. Statistically significant differences in the mean ADC values were found between grade I and grade III meningiomas (p = 0.008) and between grade II and grade III meningiomas (p = 0.012). There were no significant differences in cell density of meningiomas (p = 0.834, p = 0.684 and p = 0.766 for grade I/II, grade II/III and grade I/III, respectively). Statistically significant differences in the values of Ki-67 index were observed between grade I and grade III meningiomas (p = 0.002) as well as between grade II and grade III gemangionas (p = 0.007). The correlation between ADC values and proliferative activity of Ki-67 was found (r = - 0.699, p = 0.001). Conclusion. DW MRI with ADC mapping can be used as an additional non-invasive method of differential diagnosis for brain meningioma