Modern aspects of studing respiratory papillomatosis. Part I. Aetiology, pathogenesis, diagnosis

The review presents the study results indicating that pathogenetic disease mechanism is based on the change in regulatory mechanisms of cell proliferation. Variety of viral types is supposed to define clinical manifestations of a disease. It is not excluded the possibility of hybridization of human papilloma virus with adenovirus, cytomegalovirus, simple herpes, Epstein-Bar virus and SV-40 viruses. The PCR method in combination with hybridization in situ is the most effective one for HPV detection. New, more informative criteria of diagnosis, treatment and prognosis of respiratory papillomatosis are assumed can be developed on the basis of the complex of contemporary potentials of molecular biology, morphology and immunology