Modern aspects of intercellular interactions and their role in genesis of tubulointersticial nephropathies

Nowadays the researchers become more interested in the mechanisms of the intercellular interactions and imbalance of the chemical reactions as the bases of development of any disease. According to the laws of the general pathology, after insulting (mechanically or infectiously) cells produce a complex of vasoactive, inflammatory and anti-inflammatory, prosclerous, apoptosis mediators - cytokines. Numerous researches are devoted to studying of the pathogenetic role of these messengers in the mechanisms of the damage of tubules and interstices, in development and progressing of proliferative processes in the tubulointersticial tissues. The results of these works allow to understand the pathogenesis of tubulointersticial nephropathies from the modern point of view, to determine the basic mechanisms of realization of pathological influence and progressing of changes in the tubulointersticial tissues. This knowledge enables to use cytokines and factors of growth as the early markers of inflammatory as well as fibrotical processes in the damaged tubulointersticial tissues which are especially important with children's nephropathies.