Current trends in the field of photodynamic therapy of osteogenic sarcoma (results of pharmaceutical and experimental studies)

The aim of the study was to summarize current trends in developing photodynamic therapy strategies for osteogenic sarcoma. Material and Methods. We searched and analyzed 153 publications available from MedLine, Scopus, WoS and RSCI databases over the past 7 years. Of these, 60 were included in the review. Results. Traditional methods of treating malignant bone tumors, such as surgery, chemotherapy and radiation therapy, have significant disadvantages, including complications, serious side effects and low efficacy. Instead, nanoparticles represent a new platform for the treatment and diagnosis of malignant bone tumors. Recent studies have shown that nanoparticles can be used to treat and diagnose various types of bone tumors, including osteogenic sarcoma. This is due to their unique structure, ability to efficiently deliver drugs, and bioavailability. In addition, the surface of nanoparticles can be modified with various molecules or materials, allowing them to acquire unique properties. For example, nanoparticles can be loaded with chemotherapeutic drugs or genes, allowing their release to be controlled and precisely targeted to osteosarcoma. Nanoparticles can also be used for photodynamic therapy. In addition, the incorporation of contrast agents or fluorescent probes into nanoparticles can improve imaging capabilities and monitor the treatment process in real time. This not only makes it possible to evaluate the effectiveness of photodynamic therapy, but also to adjust the treatment plan to achieve the best results for each patient. Conclusion. Multifunctional nanoparticles are a promising tool for an individual approach to the treatment of osteogenic sarcoma using photodynamic therapy and improving the prognosis for patients.