Comparative in vitro activity of antimycotics against the causative agents of bronchopulmonary aspergillosis

We evaluated and analyzed levels of susceptibility to modern antifungals for 12 causative agents of aspergillosis: Aspergillus flavipes, A. flavus, A. fumigatus, A. glaucus, A. nidulans, A. niger, A. ochraceus, A. oryzae, A. sydowii, A. terreus, A. ustus, A. versicolor. Determination of antimycotic susceptibility of 217 clinical strains of Aspergillus spp. carried out by the broth microdilution method with determination of MIC (pg/ml) (the «Sensititre» system). We established that causative agents of aspergillosis differed by levels of susceptibility to amphotericin B. We also observed high activity of voriconazole, itraconazole, and posaconazole against Aspergillus spp., except some strains of A. ustus (reduced susceptibility to azoles, testing before treatment is required), and several strains of A. nidulans and A. niger.