Comparative efficacy of moxifloxacine and cyprofloxacine in prevention of febrile neutropenia in patients with haematological malignancies

The comparative efficacy of moxifloxacine and cyprofloxacine in prevention of febrile neutropenia (FN) was assessed in patients with hematological malignancies. Of the examined 113 patients (315 cases with neutropenia), 57 received FN prevention with moxifloxacine and 56 with cyprofloxacine. Moxifloxacine-containing regimen was found to be more effective than cyprofloxacine. FN prevention with cyprofloxacine was unsuccessful for patients with high risk of developing infection and antibacterial therapy was required for all of them. For moxifloxacine-treated patients, antibacterial therapy was given in only 64,6 % cases, the remaining patients (35,4 %) had effective FN prevention (p