Comparative efficacy of mildronate, mexidole and trimetazidine in chronic heart failure caused by the occlusion of the left coronary artery descending branch

It is shown that occlusion of the left coronary artery descending branch (OLCADB) leads to chronic heart failure (CHF) in animals within 28 days, as it is evidenced by the negative hemodynamic changes and high percentage of myocardium necrosis zones. Mildronate and, lately, mexidole displayed cardio-protective effect in CHF experimental condition limiting hemodynamic changes and myocardium necrotic zone in animals. Trimetazidine proved ineffective when administered in this model of CHF.