Comparative assessment of chemoradiotherapy for patients with nasopharyngeal cancer with respect to regimen of dose fractionation and chemotherapy modes

Results of chemoradiotherapy for 103 nasopharyngeal cancer patients were studied. The assessment of treatment efficacy showed that beneficial results were obtained in cases of combination of radiation therapy with 2 courses of polychemotherapy including platinum. A radiation therapy regimen of daily dose fractionation according to the schedule 1 + 1,5 Gy allowed the total tumor dose to be increased not increasing the incidence of radiation-induced reactions. Adjuvant polychemotherapy is recommended after 3-4 courses of chemoradiotherapy, thus improving survival.