Protective effect of modified detonation-synthesized nanodiamonds on nickel and chromium ion-induced allergic contact dermatitis in guinea pigs

The artic1e presents the comparative study of the protective effects of modified nanodiamonds (MND), obtained by detonation synthesis, on nicke1 and chromium ion-induced a11ergic contact dermatitis (ACD) in guinea pigs. Treatment with MND exerted protective effects on guinea pig skin exposed to systematic app1ication of nicke1 ions. No MND-mediated protective effects were found in case of systematic app1ication of chromium ions on the skin of experimenta1 anima1s. The differences in the effects were caused by the differentia1 adsorption properties of MND for nicke1 and chromium ions. Resu1ts of atomic-adsorption spectroscopy of the skin samp1es showed that MND effective1y bound nicke1 ions and did not adsorb chromium ions. The authors discuss prospects of the use of МНА as the new adsorbent agent for prevention ACD caused by nicke1 ions.